Speaker
Description
BrainGlobe is a community-driven initiative built around a set of interoperable, user-friendly, open-source software tools for neuroanatomy. It provides atlases for human, mouse, rat and zebrafish brains through a consistent interface. Each atlas includes a “standard” reference image for sample registration and corresponding brain region segmentations. This allows data from several samples to be analysed in the same coordinate space, within and across studies.
Neuroscience increasingly recognises the need to study brain function in more diverse species. BrainGlobe is species- and imaging-modality agnostic and is therefore a natural fit to enable the necessary data analysis. However, this requires novel atlases.
Working with expert neuro-anatomists studying emerging model organisms, we have created a novel digital brain atlas for the Eurasian blackcap Sylvia atricapilla. We have additionally incorporated existing atlases for the Mexican blind cavefish Astyanax mexicanus and axolotl Ambystoma mexicanum into BrainGlobe.
This work shows how BrainGlobe facilitates collaboration between anatomists, microscopists and software developers with large benefits to cutting-edge research. Going forward, we hope atlas-based image analysis is expanded to even more species, and other organs.
| Authors | Alessandro A Felder*, Niko Sirmpilatze, Saima Abdus, David Pérez-Suárez, Igor Tatarnikov, Sofía Miñano, Kimberly Meechan, Will Graham, Viktor M Plattner, Robert Kozol, Simon Weiler, Adam L Tyson |
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| Keywords | Atlas, anatomy, neuroscience, software, napari, python |
