Speaker
Description
This study presents a comprehensive computational and experimental analysis of long non-coding RNAs (lncRNAs) in cortical neuron differentiation from human embryonic stem cells (hESCs). Using a systematic workflow, we identified lncRNAs overexpressed at late stages of neural differentiation and characterized their expression, subcellular localization, sequence features, and regulatory interactions. K-mer profiling revealed distinct lncRNA clusters with unique sequence signatures, suggesting diverse functional roles in neural differentiation and brain tissue specificity. Notably, certain clusters were linked to ribosomal function, epigenetic regulation, and chromatin remodeling, highlighting the multifaceted contributions of lncRNAs to neural development. By illuminating the landscape of lncRNA expression during cortical neuron differentiation, this work advances our understanding of lncRNA functions in neurodevelopment and underscores their potential as biomarkers or therapeutic targets in neurological disorders.
| Author(s) | Annalaura Tamburrini, Mirko Giuseppe Scrivano, Ivan Molineris, Andrea Lauria, Francesca Anselmi, Daniela Donna, Chiara Bugelli, Livia Caizzi and Salvatore Oliviero |
|---|---|
| Affiliation(s) | Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università degli Studi di Torino ed IIGM, Candiolo, Torino |
